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Curr Opin Biotechnol. 2003 Oct;14(5):454-9.

Metabolic engineering for the microbial production of 1,3-propanediol.

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DuPont Central Research & Development Experimental Station, 328/245A Wilmington, DE 19880-0328, USA.


Improvements in the biological production of 1,3-propanediol, a key component of an emerging polymer business, have been realized. Utilizing genes from natural strains that produce 1,3-propanediol from glycerol, metabolic engineering has enabled the development of a recombinant strain that utilizes the lower cost feedstock D-glucose. This accomplishment bodes well for future metabolic engineering efforts and, ultimately, for increased societal benefit obtained through the production of chemicals from renewable resources.

[Indexed for MEDLINE]

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