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Curr Opin Chem Biol. 2003 Oct;7(5):580-5.

Protein tyrosine kinases Src and Csk: a tail's tale.

Author information

1
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. pcole@jhmi.edu

Abstract

Csk and Src are two protein tyrosine kinases with similar amino acid sequences but very different structures and functions. Csk catalyzes a tail phosphorylation reaction on Src and thereby restrains Src's activity and oncogenic potential. Comparative analysis of the domain interactions in these enzymes provides a lesson in signalling diversity and mechanisms of enzyme regulation. The molecular basis of the specificity of Csk targeting the Src tail appears to involve both local and long-range interactions and illustrates the complexity of selective targeting in post-translational modification.

PMID:
14580561
DOI:
10.1016/j.cbpa.2003.08.009
[Indexed for MEDLINE]

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