Better late than never for repair of miscoding lesions within a transcribed template

Mol Cell. 2003 Oct;12(4):799-800. doi: 10.1016/s1097-2765(03)00403-9.

Abstract

Transcription does not always stall at base damage in DNA and can create mutated transcripts from miscoding lesions. In this issue of Molecular Cell, present genetic analysis of E. coli to indicate that the highly mutagenic purine modification, 8-oxoguanine, is subject to transcription-coupled repair despite transcriptional bypass and generation of mutant transcripts.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Codon, Nonsense / genetics*
  • DNA Damage / genetics*
  • DNA Repair / genetics*
  • Genes, Regulator / genetics*
  • Guanine / analogs & derivatives*
  • Guanine / metabolism
  • Humans
  • Mutation / genetics

Substances

  • Codon, Nonsense
  • 8-hydroxyguanine
  • Guanine