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Mol Cell. 2003 Oct;12(4):795-6.

Adding facets to TNF signaling. The JNK angle.

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Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.


In the October 3 issue of Cell, Deng et al. (2003) report that a JNK-dependent mitochondrial signal, the release of Smac/DIABLO, is required for TNF-induced caspase 8 activation and apoptosis. This process is interceded by a novel processed form of the BH3 only protein Bid.

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