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Bioessays. 2003 Nov;25(11):1061-70.

Human severe combined immune deficiency and DNA repair.

Author information

1
Department of Transfusion Medicine, University of Ulm, Germany. klaus.schwarz@medizin.uni-ulm.de

Abstract

Human severe combined immune deficiency (SCID) is the most serious inherited immunological deficit. Recent work has revealed defects in the predominant pathway for double-strand break repair called nonhomologous DNA end joining, or NHEJ. Progress in the biochemistry and genetics of NHEJ and of human SCID has proven to be synergistic between these two fields in a manner that covers the range from biochemical etiology to considerations about possible gene therapy for the B- SCID patients.

PMID:
14579247
DOI:
10.1002/bies.10344
[Indexed for MEDLINE]
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