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Antimicrob Agents Chemother. 2003 Nov;47(11):3663-6.

Simulation of human gentamicin pharmacokinetics in an experimental Enterococcus faecalis endocarditis model.

Author information

1
Laboratoire d'Antibiologie, Unité UPRES EA 1156, Faculté de Médecine, and Laboratoire de Pharmacologie et de Toxicologie, CHU Nantes, France.

Abstract

Significant differences between animal and human pharmacokinetics may be responsible for the conflicting results of experimental studies. This study determined the impact of human pharmacokinetic simulation (HPS) on gentamicin activity in an Enterococcus faecalis endocarditis model. The decrease in bacterial counts was greater with HPS than with a dose-equivalent regimen without HPS.

PMID:
14576143
PMCID:
PMC253777
[Indexed for MEDLINE]
Free PMC Article

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