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Antimicrob Agents Chemother. 2003 Nov;47(11):3653-6.

G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate.

Author information

1
Departamento Micología, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr. Carlos G. Malbrán, Hospital J. A. Fernandez, Buenos Aires, Argentina. lrodero@anlis.gov.ar

Abstract

Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.

PMID:
14576140
PMCID:
PMC253790
DOI:
10.1128/aac.47.11.3653-3656.2003
[Indexed for MEDLINE]
Free PMC Article

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