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Eur J Med Chem. 2003 Oct;38(10):899-911.

Synthesis, cytotoxicity and antiviral activity of podophyllotoxin analogues modified in the E-ring.

Author information

1
Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain. macg@usal.es

Abstract

Several podophyllotoxin derivatives modified in the E-ring were prepared and evaluated for their cytotoxicity on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28) and for their antiherpetic activity against Herpes simplex virus type II. The trimethoxyphenyl moiety was oxidized to ortho-quinone and further condensed with diamines and enamines to form different heterocycles. Most of the compounds maintained their cytotoxicity at the muM level and some of them showed antiherpetic activity.

PMID:
14575937
[Indexed for MEDLINE]

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