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J Theor Biol. 2003 Nov 21;225(2):147-51.

Does tumor growth follow a "universal law"?

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1
Dip. Neuroscience, Universita di Torino, C. Raffaello 30, 10125, Torino, Italy. caterina.guiot@unito.it

Abstract

A general model for the ontogenetic growth of living organisms has been recently proposed. Here we investigate the extension of this model to the growth of solid malignant tumors. A variety of in vitro and in vivo data are analysed and compared with the prediction of a "universal" law, relating properly rescaled tumor masses and tumor growth times. The results support the notion that tumor growth follows such a universal law. Several important implications of this finding are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion.

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PMID:
14575649
DOI:
10.1016/s0022-5193(03)00221-2
[Indexed for MEDLINE]

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