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J Nat Prod. 2003 Oct;66(10):1324-7.

Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.

Author information

1
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, Republic of China.

Abstract

Three new [n-pentyl beta-carboline-1-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.

PMID:
14575431
DOI:
10.1021/np030277n
[Indexed for MEDLINE]

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