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Curr Opin Oncol. 1992 Dec;4(6):1073-9.

Cisplatin and platinum analogues: recent advances.

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Department of Medicine, Brockton/W. Roxbury VAMC, MA 02401.


Cisplatin is a critically important antineoplastic agent employed in treating patients who have a broad spectrum of neoplasms. Resistance to this agent poses a serious clinical dilemma. The objective of this review is to summarize the principal mechanisms that contribute to cytotoxicity by this agent and underlie resistance. Knowledge of these processes provides a rational basis for developing therapeutic strategies to circumvent resistance.

[Indexed for MEDLINE]

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