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Trends Cell Biol. 2003 Nov;13(11):553-7.

Ran in the spindle checkpoint: a new function for a versatile GTPase.

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Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Johns Hopkins University, 115 West University Parkway, Baltimore, MD 21210, USA.


The small GTPase Ran has a well-established role in nucleocytoplasmic trafficking. In recent years, the repertoire of Ran has expanded to include regulation of spindle assembly, formation of the nuclear envelope and DNA replication. Now, new studies further extend the role of Ran to regulating the spindle checkpoint during mitosis.

[Indexed for MEDLINE]

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