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FEBS Lett. 2003 Oct 23;553(3):355-9.

Inhibition of influenza A virus sialidase activity by sulfatide.

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Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 422-8526 Shizuoka, Japan.


Sulfatide, which binds to influenza A viruses and prevents the viral infection, was found to inhibit the sialidase activities of influenza A viruses in a pH-dependent manner. The kinetic parameters of the effect of sulfatide on the sialidase activities of human influenza A viruses using fluorometric assay indicated that sulfatide was a powerful and non-competitive type inhibitor in low-pH conditions.

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