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Behav Neurosci. 2003 Oct;117(5):927-38.

Oral cocaine seeking by rats: action or habit?

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  • 1Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, England, UK.

Abstract

Having established that the presence of cocaine in a 10% (wt/vol) sucrose solution enhanced the reinforcing properties of the solution in a dose-dependent manner, the authors investigated the susceptibility of oral cocaine seeking to outcome devaluation. Rats were trained to perform different instrumental responses for a cocaine-sucrose and a lemon-sucrose solution. An aversion was then conditioned from either the cocaine-sucrose or the lemon-sucrose solution by pairing consumption with lithium chloride. When instrumental performance was subsequently tested in extinction, the rats performed the lemon-sucrose response less if this solution, rather than cocaine-sucrose, had been devalued by aversion conditioning. By contrast, performance of the cocaine-sucrose response was unaffected by whether the cocaine-sucrose or the lemon-sucrose solution had been devalued.

PMID:
14570543
DOI:
10.1037/0735-7044.117.5.927
[PubMed - indexed for MEDLINE]
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