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J Am Chem Soc. 2003 Oct 29;125(43):13094-105.

Biosynthesis of vitamin B1 in yeast. Derivation of the pyrimidine unit from pyridoxine and histidine. Intermediacy of urocanic acid.

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1
Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1.

Abstract

Incorporation studies with 13C-, 15N-, and 2H-labeled substrates, followed by NMR analysis, show that the pyrimidine unit of thiamin (Vitamin B1) originates from a C5N fragment, derived from C-2',2,N,C-6,5,5' of pyridoxol (Vitamin B6) and an N-C-N fragment derived from L-histidine. Urocanic acid serves as an intermediate on the route of the N-C-N fragment of histidine into the thiamin pyrimidine.

PMID:
14570482
DOI:
10.1021/ja030261j
[Indexed for MEDLINE]
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