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Nat Rev Mol Cell Biol. 2003 Oct;4(10):767-76.

Ras GTPases: integrins' friends or foes?

Author information

1
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Erratum in

  • Nat Rev Mol Cell Biol. 2004 Jan;5(1):75.

Abstract

Integrins are cell-surface receptors that mediate and coordinate cellular responses to the extracellular matrix (ECM). Cellular signalling pathways can regulate cell adhesion by altering the affinity and avidity of integrins for ECM. The Ras family of small G proteins, which includes H-ras, R-ras and Rap, are important elements in cellular signalling pathways that control integrin function.

PMID:
14570053
DOI:
10.1038/nrm1229
[Indexed for MEDLINE]

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