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Nat Rev Mol Cell Biol. 2003 Oct;4(10):757-66.

The nuclear pore complex: nucleocytoplasmic transport and beyond.

Author information

1
Maurice E. Müller Institute for Structural Biology, Biozentrum, University of Basel, Switzerland. birthe.fahrenkrog@unibas.ch

Abstract

Over the past two years, it has become evident that there is an unexpected link between nuclear pore complex structure and dynamics, nucleocytoplasmic transport and chromosome segregation. In addition, a tomographic three-dimensional reconstruction of native nuclear pore complexes preserved in thick amorphous ice has unveiled a number of new structural features of this supramolecular machine. These data, together with some of the elementary physical principles that underlie nucleocytoplasmic transport, will be discussed in this review.

PMID:
14570049
DOI:
10.1038/nrm1230
[Indexed for MEDLINE]

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