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Arch Pathol Lab Med. 1992 Dec;116(12):1366-7.

Unusual bilateral renal histiocytosis. Extranodal variant of Rosai-Dorfman disease.

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  • 1Pathology Department, Central Laboratory Ministry of Health, Riyadh, Kingdom of Saudi Arabia.


A 37-year-old Bangladeshi presented with large bilateral masses involving the hilus of the kidneys. No lymphadenopathy was noted. Nephrectomy was performed. Histopathologically, it revealed a lymphohistiocytic and plasma cell inflammatory tumoral proliferation with characteristic lymphophagocytosis by the S100-positive-CD1-negative histiocytes. Extranodal presentation of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) should be entertained in the differential diagnosis of bilateral masses involving the kidneys.

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