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Mol Immunol. 2003 Nov;40(7):395-405.

Lactoferrin--a multifunctional protein with antimicrobial properties.

Author information

1
Metalloprotein Research Group, Randall Centre for Molecular Mechanisms of Cell Function, King's College London, 3.6 A New Hunt's House, Guy's Campus, London SE1 1UL, UK. sebastian.farnaud@kcl.ac.uk

Abstract

Lactoferrin is a member of the transferrin family of iron-binding proteins. Numerous functions have been reported and continue to be reported for the protein, some of which are related to its iron-binding properties. Its extensive antimicrobial activities were originally attributed to its ability to sequester essential iron, however, it is now established that it possesses bactericidal activities as a result of a direct interaction between the protein or lactoferrin-derived peptides. This article reviews the antimicrobial activities of lactoferrin and discusses the potential mode of action of lactoferrin-derived cationic peptides against Gram-negative bacteria in the light of recent studies.

PMID:
14568385
DOI:
10.1016/s0161-5890(03)00152-4
[Indexed for MEDLINE]

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