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Cell. 2003 Oct 17;115(2):135-8.

Targeting survival: integration site selection by retroviruses and LTR-retrotransposons.

Author information

1
Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Rd., La Jolla, CA 92037, USA. bushman@salk.edu

Abstract

Replication of retroviruses and retrotransposons depends on selecting a favorable chromosomal site for integration of their genomic DNA. Different retroelements meet this challenge by targeting distinctive chromosomal regions. Despite these differences, recent data hints at a common targeting mechanism-tethering of integration complexes to proteins bound at favorable sites.

PMID:
14567911
DOI:
10.1016/s0092-8674(03)00760-8
[Indexed for MEDLINE]
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