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Nurs Clin North Am. 2003 Sep;38(3):447-64, vi.

Nonopioid and adjuvant analgesics in chronic pain management: strategies for effective use.

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University of Wisconsin Hospital & Clinics, 600 Highland Avenue, F6/121-1535, Madison, WI 53792, USA.


Nonopioid and adjuvant analgesics encompass a huge range of heterogenous drugs that differ chemically and mechanistically. These drugs generally are prescribed for mild-to-moderate pain, as coanalgesics for severe pain, or to target specific pain-generating mechanisms. This article provides an overview of some of the more commonly used nonopioid and adjuvant analgesics used to treat chronic pain, including salicylates, acetaminophen, nonsteroidal anti-inflammatory drugs, tricyclic antidepressants, anticonvulsants, N-Methyl-D-Aspartate receptor antagonists, lidocaine, skeletal muscle relaxants, and topical analgesics.

[Indexed for MEDLINE]

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