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Genes Chromosomes Cancer. 2003 Dec;38(4):349-56.

Uterine leiomyoma in the Eker rat: a unique model for important diseases of women.

Author information

1
University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas 78957, USA. cwalker@odin.mdacc.tmc.edu

Abstract

Eker rats carry a defect in the Tsc-2 tumor suppressor gene and female Eker rats develop uterine leiomyoma with a high frequency. The presentation, response to hormones and molecular alterations in these mesenchymal smooth muscle tumors, closely resembles their cognate human disease. Female rats and tumor-derived cell lines from Eker rat leiomyomas (ELT lines) have been developed as an in vivo/in vitro model system for preclinical studies to identify novel therapeutic agents for this disease and for studying disease pathogenesis. In addition to serving as a model for uterine leiomyoma, Eker rats have proven valuable for studying lymphangioleiomyomatosis, a related proliferative smooth muscle disease of women.

PMID:
14566855
DOI:
10.1002/gcc.10281
[Indexed for MEDLINE]

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