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Nat Neurosci. 2003 Nov;6(11):1137-8. Epub 2003 Oct 19.

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis.

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Division of Cell Biology, Faculty of Health Sciences, University of Linköping, S-581 85 Linköping, Sweden.


We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopolysaccharide, but their pyretic capacity in response to centrally administered PGE2 was intact. Our findings identify mPGES-1 as the central switch during immune-induced pyresis and as a target for the treatment of fever and other PGE2-dependent acute phase reactions elicited by the brain.

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