Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):813-5. doi: 10.1081/NCN-120022660.

Abstract

Synthesis and biological activity of 7- and 9-isomers (Z+E) of methylenecyclopropane analogues of 2-aminopurine nucleosides is described. The (S,Z)-9-isomer is a substrate for xanthine oxidase.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Aminopurine / analogs & derivatives*
  • 2-Aminopurine / chemical synthesis*
  • 2-Aminopurine / chemistry
  • 2-Aminopurine / metabolism
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Cyclopropanes
  • Indicators and Reagents
  • Isomerism
  • Substrate Specificity
  • Xanthine Oxidase / metabolism

Substances

  • Antiviral Agents
  • Cyclopropanes
  • Indicators and Reagents
  • 2-Aminopurine
  • Xanthine Oxidase