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Immunity. 2003 Oct;19(4):469-77.

Stress management: MHC class I and class I-like molecules as reporters of cellular stress.

Author information

1
Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

The evolutionarily ancient intracellular stress response protects cells from the effects of external and internal forces which perturb cellular metabolism. Members of the major histocompatibility complex (MHC) class I-like superfamily act as cell surface indicators of the intracellular stress response. Cellular immunity employs these indicators as a cue for elimination of damaged, infected, and malignant cells, promoting the health of the individual and the evolutionary success of the species.

PMID:
14563312
DOI:
10.1016/s1074-7613(03)00272-3
[Indexed for MEDLINE]
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