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Gastroenterol Clin North Am. 2003 Sep;32(3):997-1019.

Cyclic vomiting syndrome: a brain-gut disorder.

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Department of Pediatrics, Feinberg School of Medicine, Northwestern University and Children's Memorial Hospital Chicago, IL 60614, USA.


Despite the "black box" surrounding CVS, the authors' understanding of this clinical entity has advanced substantially in the last decade as a result of an international interdisciplinary clinical and research effort. Although CVS is now recognized as a unique clinical entity, patients still undergo innumerable hospitalizations and diagnostic tests. Although controlled therapeutic studies are lacking, reasonably effective empiric approaches have been developed by trial and error using anti-migraine, anti-emetic, and anti-epileptic regimens. The ongoing investigations of migraine mechanisms through NMR spectroscopy, mitochondrial DNA mutations and cellular energetics, corticotropin-releasing factor and gastric motility, and brainstem regulation of autonomic function may lead to breakthroughs in the understanding of and new therapies for CVS in the next decade.

[Indexed for MEDLINE]

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