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Gastroenterol Clin North Am. 2003 Sep;32(3):877-89, vi-vii.

Neonatal hemochromatosis.

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Institute of Liver Studies, King's College Hospital, London, UK.


Neonatal hemochromatosis is a rare gestational condition in which iron accumulates in the fetal tissues in a distribution like that seen in hereditary hemochromatosis. Extensive liver damage is the dominant clinical feature, with late fetal loss or early neonatal death. NH recurs within sibships at a rate higher than that predicted for simple Mendelian autosomal-recessive inheritance, possibly suggesting the role of a maternal factor. Immunomodulation during pregnancy at risk appears to lessen the severity of disease.

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