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Genes Dev. 2003 Oct 15;17(20):2514-9.

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis.

Author information

1
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9133, USA. jin.jiang@utsouthwestern.edu

Abstract

In a genetic screen for mutations that restrict cell growth and organ size, we identified a new tumor suppressor gene, dMST, which encodes the Drosophila homolog of the mammalian Ste20 kinase family members MST1 and MST2. Loss-of-function mutations in dMST result in overgrown tissues containing more cells of normal size. dMST mutant cells exhibit elevated levels of Cyclin E and DIAP1, increased cell growth and proliferation, and impaired apoptosis. dMST forms a complex with Sav and Wts, two tumor suppressors also implicated in regulating both cell proliferation and apoptosis, suggesting that they act in common pathways.

PMID:
14561774
PMCID:
PMC218145
DOI:
10.1101/gad.1134003
[Indexed for MEDLINE]
Free PMC Article

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