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AJNR Am J Neuroradiol. 2003 Oct;24(9):1834-6.

Model of reversible cerebral ischemia in a monkey model.

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Department of Radiology, University of Pittsburgh Medical Center, PA 15213, USA.


We have developed a model of reversible cerebral ischemia in a high-level nonhuman primate. By using endovascular techniques, the posterior cerebral artery is permanently occluded with coils, and the ipsilateral middle cerebral artery is temporarily occluded with a balloon. The balloon can be deflated and/or removed to reestablish flow at precise time intervals. Functional imaging of the brain can be performed during occlusion and reperfusion, since the balloon can be deflated or removed in a scanner.

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