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Biochim Biophys Acta. 2003 Oct 13;1616(2):107-11.

Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell line.

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Nutrition, Croissance et Cancer, Inserm Emi-U 0211, Faculté de Médecine, 2 Bd Tonnellé, 37032 Tours Cedex, France.


This work reports the finding of a unique fast inward sodium current (I(Na)) in MDA-MB-231 cells which is missing in MDA-MB-468 cells and in MCF-7 cells. This current is high-voltage-activated and displays a window current at the membrane potential of MDA-MB-231 cells. This current is blocked by high concentrations of tetrodotoxin (TTX). In MDA-MB-231 cells, which are the most invasive cells among the three cell lines tested, proliferation and migration were not sensitive to TTX while invasion was reduced by approximately 30%. These experiments suggest that I(Na) is involved in the invasion process, probably through its participation to the regulation of the intracellular sodium homeostasis.

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