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BMC Gastroenterol. 2003 Oct 16;3:27.

Clinical and histological features of nonalcoholic steatohepatitis in Iranian patients.

Author information

1
Digestive Diseases Research Center-Imam Hospital, Tehran University of Medical Sciences, Iran. dr_Bahrami@hotmail.com

Abstract

BACKGROUND:

Although several studies have been performed on risk factors and natural course of NASH, it seems that NASH tends to be more than a disease confined to strict boundaries. The objective of this study was to assess the clinical and paraclinical features and risk factors for non-alcoholic steatohepatitis (NASH) patients in an Iranian population

METHODS:

Patients with histologically confirmed NASH who had elevated liver aminotransaminases, negative serologic markers of viral or autoimmune hepatitis and no findings in favor of metabolic liver disease were enrolled. A careful history was taken regarding alcohol intake.

RESULTS:

53 patients consisting of 32 male and 21 female entered the study. The mean age was 37.8 +/- 11.3 years. Twenty-six patients (55.3%) were overweight, 15 (31.9%) obese, 40 (75.5%) dyslipidemic, and three patients (5.7%) were diabetic. Liver biopsy showed mild steatosis in 35.7%, moderate steatosis in 53.6%, and severe forms in 10.7%. In 80.2% of patients, portal inflammation was present, and 9.4% had cirrhosis. The amount of increase in liver enzymes bore no relationship with fibrosis, portal inflammation, and degree of steatosis.

CONCLUSIONS:

The patients in our study showed a male predominancy and were somewhat younger than other studies.

PMID:
14561231
PMCID:
PMC270051
DOI:
10.1186/1471-230X-3-27
[Indexed for MEDLINE]
Free PMC Article
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