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J Med Chem. 2003 Oct 23;46(22):4799-802.

Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.

Author information

1
Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

Abstract

Triphosphate 1c is a potent competitive inhibitor of wild-type HIV-1 reverse transcriptase with K(i) close to ddATP. The E-isomer 2c is about 30-times weaker. Triphosphates 1c and 2c interact with the same active site of reverse transcriptase as ddATP. The extent of inhibition of two mutant forms of reverse transcriptase (RT), RT(M184V) and RT(M184I), with triphosphate 1c was about 5 and 8 times lower than that of wild-type RT(wt).

PMID:
14561099
DOI:
10.1021/jm030048y
[Indexed for MEDLINE]

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