PMID- 14558924
OWN - NLM
STAT- MEDLINE
DCOM- 20040422
LR  - 20131121
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 13
IP  - 8
DP  - 2003 Aug
TI  - Possible induction of Graves' disease and painless thyroiditis by
      gonadotropin-releasing hormone analogues.
PG  - 815-8
AB  - Prolonged administration of gonadotropin-releasing hormone (GnRH) analogues
      induce a decrease in serum estrogen level, which may aggravate subclinical or
      mild autoimmune thyroid disease. Two patients developed Graves' thyrotoxicosis in
      association with an increase in anti-thyrotropin (TSH) receptor antibody
      activities at 4 months after initiation of buserelin acetate. GnRH analogue
      therapy was discontinued at the time of diagnosis but it took more than 2 years
      of methimazole therapy to obtain remission of Graves' disease. Another patient
      developed painless thyroiditis in association with an increase in antithyroid
      microsomal antibodies at 4 months after initiation of leuprolide acetate. These
      results indicate that GnRH analogues possibly induce clinical onset of Graves'
      thyrotoxicosis or destruction-induced thyrotoxicosis. Clinicians should be aware 
      of this phenomenon. All patients who are to receive GnRH analogue therapy should 
      be examined for antithyroid antibodies and family history of autoimmune thyroid
      disease, and should be followed accordingly.
FAU - Amino, Nobuyuki
AU  - Amino N
AD  - Department of Laboratory Medicine, Osaka University Graduate School of Medicine, 
      Suita, Osaka, Japan. namino@labo.med.osaka-u.ac.jp
FAU - Hidaka, Yoh
AU  - Hidaka Y
FAU - Takano, Toru
AU  - Takano T
FAU - Tatsumi, Ke-ita
AU  - Tatsumi KI
FAU - Izumi, Yukiko
AU  - Izumi Y
FAU - Nakata, Yukiko
AU  - Nakata Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Immunoglobulins, Thyroid-Stimulating)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*adverse effects/*analogs & derivatives
MH  - Graves Disease/*chemically induced
MH  - Humans
MH  - Immunoglobulins, Thyroid-Stimulating/blood
MH  - Middle Aged
MH  - Pain
MH  - Thyroiditis/*chemically induced/physiopathology
MH  - Thyroiditis, Autoimmune/chemically induced
MH  - Thyrotropin/blood/immunology
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
EDAT- 2003/10/16 05:00
MHDA- 2004/04/23 05:00
CRDT- 2003/10/16 05:00
PHST- 2003/10/16 05:00 [pubmed]
PHST- 2004/04/23 05:00 [medline]
PHST- 2003/10/16 05:00 [entrez]
AID - 10.1089/105072503768499707 [doi]
PST - ppublish
SO  - Thyroid. 2003 Aug;13(8):815-8. doi: 10.1089/105072503768499707.