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Arthritis Rheum. 2003 Oct 15;49(5):709-15.

Microscopic polyangiitis and polyarteritis nodosa: how and when do they start?

Author information

1
Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, France.

Abstract

OBJECTIVE:

To describe initial clinical symptoms attributable to microscopic polyangiitis (MPA) or polyarteritis nodosa (PAN).

METHODS:

We retrospectively reviewed the medical files of 72 patients (mean followup 6.7 years) with biopsy-proven MPA (n = 36) or PAN (n = 36).

RESULTS:

Initial manifestations were similar in both entities except for peripheral neuropathy (P = 0.02) and gastrointestinal tract involvement (P = 0.006), which were significantly more frequent in PAN, and general signs alone in MPA (8%; P = 0.02). The mean time to diagnosis was 9.8 +/- 19.4 months; 35% of the patients died and 26% relapsed; significantly more MPA than PAN patients relapsed (P = 0.03). Time to diagnosis >/=90 days was associated with a trend toward more patients relapsing (P = 0.12), but not with an increased risk of mortality.

CONCLUSION:

Initial symptoms of MPA and PAN are usually nonspecific and last for several months before the diagnosis is made. A longer time to diagnosis is associated with a tendency to a higher relapse rate.

PMID:
14558058
DOI:
10.1002/art.11387
[Indexed for MEDLINE]
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