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Trends Mol Med. 2003 Oct;9(10):409-13.

Death and the retrovirus.

Author information

1
Unité de Rétrovirologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 cedex 15, Paris, France.

Abstract

A flurry of new papers has shown that HIV reverse transcription is vulnerable to G-->A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion.

PMID:
14557052
DOI:
10.1016/j.molmed.2003.08.008
[Indexed for MEDLINE]

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