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FEMS Immunol Med Microbiol. 2003 Oct 24;39(1):45-50.

Escherichia coli bind to urinary bladder epithelium through nonspecific sialic acid mediated adherence.

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Division of Infectious Diseases and Clinical Microbiology, Department of Medicine, School of Medicine, Adnan Menderes University, 09100 Aydin, Turkey.


The first step in the bacterial colonization and infection of uropathogenic Escherichia coli is adherence to uroepithelium. Over 80% of all urinary tract infections are caused by E. coli. Uropathogenic E. coli express several adherence factors including type 1 and P fimbriae, which mediate attachment to the uroepithelium through specific binding to different glycoconjugate receptors. We showed that P and type 1 fimbriae are not the sole adhesins on uropathogenic E. coli and sialic acid also mediates nonspecific bacterial adherence of uropathogenic E. coli and urinary bladder epithelium.

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