Format

Send to

Choose Destination
FEMS Immunol Med Microbiol. 2003 Oct 24;39(1):45-50.

Escherichia coli bind to urinary bladder epithelium through nonspecific sialic acid mediated adherence.

Author information

1
Division of Infectious Diseases and Clinical Microbiology, Department of Medicine, School of Medicine, Adnan Menderes University, 09100 Aydin, Turkey. serhansakarya@yahoo.com

Abstract

The first step in the bacterial colonization and infection of uropathogenic Escherichia coli is adherence to uroepithelium. Over 80% of all urinary tract infections are caused by E. coli. Uropathogenic E. coli express several adherence factors including type 1 and P fimbriae, which mediate attachment to the uroepithelium through specific binding to different glycoconjugate receptors. We showed that P and type 1 fimbriae are not the sole adhesins on uropathogenic E. coli and sialic acid also mediates nonspecific bacterial adherence of uropathogenic E. coli and urinary bladder epithelium.

PMID:
14556995
DOI:
10.1016/S0928-8244(03)00185-8
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center