Format

Send to

Choose Destination
Neuron. 2003 Oct 9;40(2):297-318.

Polarized domains of myelinated axons.

Author information

1
Department of Cell Biology and Neurology, Program in Molecular Neurobiology, Skirball Institute of Biomedical Research, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA. jim.salzer@med.nyu.edu

Abstract

The entire length of myelinated axons is organized into a series of polarized domains that center around nodes of Ranvier. These domains, which are crucial for normal saltatory conduction, consist of distinct multiprotein complexes of cell adhesion molecules, ion channels, and scaffolding molecules; they also differ in their diameter, organelle content, and rates of axonal transport. Juxtacrine signals from myelinating glia direct their sequential assembly. The composition, mechanisms of assembly, and function of these molecular domains will be reviewed. I also discuss similarities of this domain organization to that of polarized epithelia and present emerging evidence that disorders of domain organization and function contribute to the axonopathies of myelin and other neurologic disorders.

PMID:
14556710
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center