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Intensive Care Med. 2003 Nov;29(11):2072-6. Epub 2003 Oct 11.

Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia.

Author information

1
Department of Clinical Pharmacy, The University of Tennessee College of Pharmacy, 26 South Dunlap, Memphis, Tennessee 38163, USA. cwood@utmem.edu

Abstract

OBJECTIVE:

To report the use of tetracyclines for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP).

DESIGN:

Observational case series.

SETTING:

. The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA.

PATIENTS AND PARTICIPANTS:

Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline.

INTERVENTIONS:

Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days.

MEASUREMENTS AND RESULTS:

Doxycycline or minocycline was successful in six of seven patients.

CONCLUSIONS:

Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.

PMID:
14556048
DOI:
10.1007/s00134-003-1811-2
[Indexed for MEDLINE]

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