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Nat Biotechnol. 2003 Nov;21(11):1305-6. Epub 2003 Oct 12.

Human antibodies from immunized donors are protective against anthrax toxin in vivo.

Author information

1
Alexion Antibody Technologies, Inc., 3985 Sorrento Valley Blvd., San Diego, California 92121, USA.

Abstract

A panel of Fabs that neutralize anthrax toxin in vitro was selected from libraries generated from human donors vaccinated against anthrax. At least two of these antibodies protect rats from anthrax intoxication in vivo. Fabs 83K7C and 63L1D bind with subnanomolar affinity to protective antigen (PA) 63, and Fab 63L1D neutralizes toxin substoichiometrically, inhibits lethal factor (LF) interaction with PA63 and binds to a conformational epitope formed by PA63.

PMID:
14555959
DOI:
10.1038/nbt891
[Indexed for MEDLINE]

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