Format

Send to

Choose Destination
See comment in PubMed Commons below
Chest. 2003 Oct;124(4):1312-7.

Effects of short-term 28% and 100% oxygen on PaCO2 and peak expiratory flow rate in acute asthma: a randomized trial.

Author information

1
Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uraguay. gurodrig@adinet.com.uy

Abstract

STUDY OBJECTIVE:

We conducted the first randomized controlled study to assess the effects of short-term 28% and 100% oxygen on PaCO(2) and peak expiratory flow rate (PEFR) in patients with acute severe asthma.

PATIENTS AND INTERVENTIONS:

Seventy-four patients (mean age, 37.9 +/- 9.7 years [+/- SD]; PEFR, 41.0 +/- 12.1% of predicted) from two emergency departments were randomized to receive 28% or 100% oxygen during 20 min.

RESULTS:

The administration of 100% oxygen significantly increases PaCO(2) (p = 0.03) and decreases PEFR (p = 0.001) as compared with administration of 28% oxygen. PaCO(2) before and during oxygen administration correlated significantly (p = 0.001) in both groups. Patients breathing 28% oxygen experienced a PaCO(2) fall; on the contrary, patients who received 100% oxygen showed an increase in PaCO(2), particularly those with PaCO(2) before oxygen treatment > 40 mm Hg.

CONCLUSIONS:

This study confirmed previous observations that oxygen dose should be variable and based on achieving and maintaining target arterial oxygen saturation measured by pulse oximetry > or = 92% rather than on prescribing predetermined concentrations or flow rates of inspired oxygen.

PMID:
14555560
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center