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Trends Biochem Sci. 1992 Oct;17(10):438-43.

Signal transduction and the actin cytoskeleton: the roles of MARCKS and profilin.

Author information

1
Laboratory of Signal Transduction, Rockefeller University, New York, NY 10021.

Abstract

MARCKS and profilin, two actin-binding proteins, are discussed to illustrate the mechanism by which extracellular signals are coupled to changes in the structure of the actin cytoskeleton. MARCKS is a filamentous actin-crosslinking protein that appears to function as an integrator of protein kinase C and calcium (Ca2+)/calmodulin signals in the regulation of actin-membrane interactions. New data suggest that profilin is activated by the coordinated action of receptor tyrosine kinases and phospholipase C-gamma 1 to stimulate the stabilization of actin filaments.

PMID:
1455513
DOI:
10.1016/0968-0004(92)90016-3
[Indexed for MEDLINE]

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