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Trends Biochem Sci. 1992 Oct;17(10):418-22.

Control of transcription factors by signal transduction pathways: the beginning of the end.

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1
Department of Pharmacology, University of California, San Diego, School of Medicine, La Jolla 92093-0636.

Abstract

Signal transduction pathways regulate gene expression by modulating the activity of nuclear transcription factors. The mechanisms that control the activity of two groups of sequence-specific transcription factors, the AP-1 and CREB/ATF proteins, are described. These factors serve as a paradigm explaining the transfer of regulatory information from the cell surface to the nucleus.

PMID:
1455510
[Indexed for MEDLINE]

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