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Trends Biochem Sci. 1992 Oct;17(10):383-7.

G proteins.

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Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235.


The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits. Thus, GTP-binding alpha-subunits and the beta gamma-subunit complex can influence the activity of effector molecules independently or simultaneously, either synergistically or in opposition, to elicit a complex constellation of cellular events.

[Indexed for MEDLINE]

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