Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 1992 Oct;17(10):374-8.

Triggering signaling cascades by receptor tyrosine kinases.

Author information

1
Howard Hughes Medical Institute, University of California, San Francisco 94143-0724.

Abstract

Growth factor receptors that are tyrosine kinases (RTKs) regulate growth and differentiation of cells in many organisms, including flies, worms, frogs, mice and humans. There has been recent progress in understanding the mechanism by which these receptors transduce signals. Worm and insect studies on RTKs have relied primarily on genetics, while the mammalian studies have employed a combination of molecular genetics and biochemistry. While many RTKs seem to have unique features, there are also many general signal transduction principles that emerge from these studies. In this review, we will focus on common signaling molecules, using RTKs from both vertebrates and invertebrates as examples.

PMID:
1455504
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center