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Carbohydr Res. 2003 Oct 10;338(21):2163-8.

Synthesis of an octamannosyled glycan chain, the key oligosaccharide structure in ER-associated degradation.

Author information

1
RIKEN, The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

Abstract

The high-mannose type decasaccharide (Man(8)GlcNAc(2)), the proposed ligand of ER residing mannosidase-like proteins (MLP), and its monoglycosylated homologue (alpha-Glc(1)Man(8)GlcNAc(2)) were synthesized. The oligosaccharide assembly was performed in a convergent and stereoselective manner, using three oligosaccharide components, a core trisaccharide having a beta-mannoside bond, a liner mannotriose, and a branched mannotetraose.

PMID:
14553976
DOI:
10.1016/s0008-6215(03)00357-4
[Indexed for MEDLINE]

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