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Trends Immunol. 2003 Oct;24(10):522-4.

Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1.

Author information

  • 1Department of Pathology, VU Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. fm.raaphorst@vumc.nl

Abstract

Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. Two recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal by normal and leukemic stem cells. This identifies Polycomb-group genes as potential targets for therapeutic intervention in leukemia, and possibly other forms of cancer.

PMID:
14552834
[PubMed - indexed for MEDLINE]
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