Abstract
In order for the immune system to generate its vast numbers of receptors, B- and T-cell receptor genes are created by recombining preexisting gene segments. This well- coordinated set of reactions is explained
MeSH terms
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Animals
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DNA Repair
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DNA-Binding Proteins
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Evolution, Molecular
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Gene Rearrangement
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Humans
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Immune System / physiology*
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Mice
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Mice, SCID
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Mice, Transgenic
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Models, Biological
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Nuclear Proteins
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Nucleic Acid Conformation
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Receptors, Antigen, B-Cell / physiology*
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Receptors, Antigen, T-Cell / physiology*
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Recombination, Genetic
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Translocation, Genetic
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VDJ Recombinases / metabolism
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VDJ Recombinases / physiology*
Substances
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DNA-Binding Proteins
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Nuclear Proteins
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Receptors, Antigen, B-Cell
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Receptors, Antigen, T-Cell
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VDJ Recombinases