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J Infect Dis. 2003 Oct 15;188(8):1146-55. Epub 2003 Sep 30.

Virological and immunological impact of tuberculosis on human immunodeficiency virus type 1 disease.

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  • 1Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106-4984, USA. zxt2@po.cwru.edu.

Abstract

Unlike other opportunistic infections associated with human immunodeficiency virus (HIV) type 1, tuberculosis (TB) occurs throughout the course of HIV-1 infection, and, as a chronic infection, its impact on viral activity is sustained. In dually infected subjects, HIV-1 load and heterogeneity are increased both locally and systemically during active TB. Studies over the past decade have indicated that Mycobacterium tuberculosis (MTB) infection supports HIV-1 replication and dissemination through the dysregulation of host cytokines, chemokines, and their receptors. Furthermore, concentrations of HIV-1 inhibitory chemokines are limited during TB and at sites of MTB infection. Cumulatively, these data indicate that TB provides a milieu of continuous cellular activation and irregularities in cytokine and chemokine circuits that are permissive of viral replication and expansion in situ. I address new research that has identified the basis for the augmentation of HIV-1 replication during TB and discuss potential immunotherapies to contain viral expansion during TB.

PMID:
14551885
DOI:
10.1086/378676
[PubMed - indexed for MEDLINE]
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