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Cancer Lett. 2003 Oct 8;200(1):41-7.

Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans.

Author information

1
Division of Toxicology, Wageningen University, 6703 HE, Wageningen, The Netherlands. hester.vanderwoude@wur.nl

Abstract

Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect.

PMID:
14550951
[Indexed for MEDLINE]

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