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FEBS Lett. 2003 Oct 9;553(1-2):3-10.

Diversification and evolution of L-myo-inositol 1-phosphate synthase.

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Plant Molecular and Cellular Genetics, Bose Institute (Centenary Building), Kolkata, India.


L-myo-Inositol 1-phosphate synthase (MIPS, EC, the key enzyme in the inositol and phosphoinositide biosynthetic pathway, is present throughout evolutionarily diverse organisms and is considered an ancient protein/gene. Analysis by multiple sequence alignment, phylogenetic tree generation and comparison of newly determined crystal structures provides new insight into the origin and evolutionary relationships among the various MIPS proteins/genes. The evolution of the MIPS protein/gene among the prokaryotes seems more diverse and complex than amongst the eukaryotes. However, conservation of a 'core catalytic structure' among the MIPS proteins implies an essential function of the enzyme in cellular metabolism throughout the biological kingdom.

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